Back to ICD-10 library
ICD-10-CM · FY 2026 APRIL UPDATE

D57.4

Sickle-cell thalassemia

Diagnosis reference

Nonbillable category

This entry is a category or subcategory. Choose the appropriate billable descendant based on the clinical documentation.

Effective periodOctober 1, 2026–September 30, 2027
SourceCMS ICD-10-CM order file
ClassificationDiagnosis · clinical modification

Related entries

Up to 30 descendants in this category

CODEDESCRIPTIONTYPE
D57.40Sickle-cell thalassemia without crisisBillable
D57.41Sickle-cell thalassemia, unspecified, with crisisCategory
D57.411Sickle-cell thalassemia, unspecified, with acute chest syndromeBillable
D57.412Sickle-cell thalassemia, unspecified, with splenic sequestrationBillable
D57.413Sickle-cell thalassemia, unspecified, with cerebral vascular involvementBillable
D57.414Sickle-cell thalassemia, unspecified, with dactylitisBillable
D57.418Sickle-cell thalassemia, unspecified, with crisis with other specified complicationBillable
D57.419Sickle-cell thalassemia, unspecified, with crisisBillable
D57.42Sickle-cell thalassemia beta zero without crisisBillable
D57.43Sickle-cell thalassemia beta zero with crisisCategory
D57.431Sickle-cell thalassemia beta zero with acute chest syndromeBillable
D57.432Sickle-cell thalassemia beta zero with splenic sequestrationBillable
D57.433Sickle-cell thalassemia beta zero with cerebral vascular involvementBillable
D57.434Sickle-cell thalassemia beta zero with dactylitisBillable
D57.438Sickle-cell thalassemia beta zero with crisis with other specified complicationBillable
D57.439Sickle-cell thalassemia beta zero with crisis, unspecifiedBillable
D57.44Sickle-cell thalassemia beta plus without crisisBillable
D57.45Sickle-cell thalassemia beta plus with crisisCategory
D57.451Sickle-cell thalassemia beta plus with acute chest syndromeBillable
D57.452Sickle-cell thalassemia beta plus with splenic sequestrationBillable
D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvementBillable
D57.454Sickle-cell thalassemia beta plus with dactylitisBillable
D57.458Sickle-cell thalassemia beta plus with crisis with other specified complicationBillable
D57.459Sickle-cell thalassemia beta plus with crisis, unspecifiedBillable

Use the complete reference

This reference does not reproduce the full tabular hierarchy, inclusion notes, Excludes1/2 notes, sequencing instructions, or seventh-character rules. Review the official tables and coding guidelines.

Open official CMS files

ICD-10-CM codes describe diagnoses. They do not have an independent Medicare PFS reimbursement amount, and billability alone does not establish coverage.